Tetramethylenedisulfotetramine, commonly known as tetramine or TETS, is a highly neurotoxic rodenticide used in hundreds of deliberate and accidental food poisoning events in China. The tetramine was extracted with a fused silica fibre coated with a 100 μm polydimethylsiloxane (PDMS) and detected by GC with a nitrogen/phosphorus detector (NPD). It is banned in the U.S. and has been responsible for several poisoning deaths in the U.S. Its properties, mechanism, clinical manifestations and management are described. The solid-phase microextraction (SPME) coupled with gas chromatography (GC) was used to develop a simple, rapid and sensitive method for the determination of tetramethylenedisulfotetramine (tetramine) in human blood. Tetramethylenedisulfotetramine is grouped with other "cage convulsants", such as picrotoxin, since they have a similar intercalating cyclical molecular structure and cause seizures through non‐competitive gamma‐aminobutyric acid (GABA) antagonism.