Sodium butyrate (NaBu), a potent histone deacetylase inhibitor, modulates the expression of a large number of genes. NaB inhibits proin- flammatory cytokine signaling pathway, thus providing proof of mechanism for its anti-inflammatory activity. It is also found that NaB induced three genes, which are known metastatic suppressors, and downregulated 11 genes, which have been shown to promote metastasis.